The 1950 Cal Poly Mustangs football team represented California Polytechnic State College—now known as California Polytechnic State University, San Luis Obispo—as a member of the California Collegiate Athletic Association (CCAA) during the 1950 college football season. Led by first-year head coach LeRoy Hughes, Cal Poly compiled an overall record of 3–7 with a mark of 0–4 in conference play, placing last out of five teams in the CCAA. The Mustangs played home games at Mustang Stadium in San Luis Obispo, California.
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